Jeanne Savage

Short CV

Research

Why are some individuals more likely than others to develop mental health problems? What makes one person susceptible to addiction while another is resilient in the face of the same life circumstances? My research aims to understand how individual differences in genetics and environment lead to different mental health outcomes. In particular, I am interested in how (genetic) heterogeneity may underlie different pathways in the development of alcohol and substance misuse, and how such pathways overlap with other psychiatric and behavioral disorders.

Highlighted publications

• Jansen, I.E.*, Savage, J.E. *, Watanabe, K., Bryois, J., Williams, D.M., Steinberg, S., … Posthuma, D. (2019). Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk. Nature Genetics, 51(3), 404-413. PMID: 30617256.

• Savage, J.E.,* Jansen, P.R.*, Stringer, S., Watanabe, K., Bryois, J., de Leeuw, C.A., … Posthuma, D. (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics, 50(7), 912-919. PMID: 29942086.

• Savage, J.E., Salvatore, J.E., Aliev, F., Edwards, A.C., Hickman, M., Kendler, K.S., … Dick, D.M. (2018). Polygenic risk scores predicting alcohol dependence symptoms across population-based and clinically ascertained samples. Alcoholism: Clinical and Experimental Research, 42(3), 520-530. PMID: 29405378.

• Salvatore, J.E.*, Savage, J.E. *, Barr, P.B., Wolen, A., Aliev, F., Vuoksimaa, E., … Dick, D.M. (2018). Incorporating functional genomic information to enhance polygenic signal and identify variants involved in gene-by-environment interaction for young adult alcohol problems. Alcoholism: Clinical and Experimental Research, 42(2), 413-423. PMID: 29121402.

• Savage, J.E. , Long, E.C., Kuo, S.I., Cooke, M.E., Su, J., Barr, P.B., Salvatore, J.E. (2017). Alcohol misuse across the lifespan: Insights from developmental studies in behavior genetics. Policy Insights from the Behavioral and Brain Sciences, 4(2), 186-193. PMID: 29430518.

• Li, J.J., Savage, J.E. , Hickman, M., Heron, J., Macleod, J., Kaprio J., Rose, R.J., Dick, D.M. (2017). Polygenic risk, personality dimensions, and adolescent alcohol use problems: A longitudinal study. Journal of Abnormal Psychology, 78(3), 442-451. PMID: 28499112.

• Savage, J.E. , Sawyers, C., Roberson-Nay, R., Hettema, J.M. (2017). The genetics of negative valence system traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 174(2), 156-177. PMID: 27196537. PMCID: PMC5349709.

• Savage, J.E. , Kaprio, J., Korhonen, T., Pulkkinen, L., Rose, R.J., Verhulst, B., Dick, D.M. (2016). The effects of social anxiety on substance use across adolescence: Results from a longitudinal study in Finland. Psychology of Addictive Behaviors, 30(4): 462-474. PMID: 27322804.

• Savage, J.E.,* Neale, Z.*, Cho, S.B., Kidd Donovan, K., Hancock, L., Kalmijn, J.A., Smith, T.L., Schuckit, M.A., Dick, D.M. (2015). Level of response to alcohol as a factor for targeted prevention in college students. Alcoholism: Clinical and Experimental Research, 39(11) 2215-2223. PMID: 26503068.

• Savage, J.E. , Verhulst, B., Copeland, W., Althoff, R.R., Lichtenstein, P., Roberson-Nay, R. (2015). A genetically informed study of the causal relation between irritability and anxious/depressed symptoms. (2015). Journal of the American Academy of Child & Adolescent Psychiatry, 54(5), 377-384. PMID: 25901774.

• Savage, J.E. , Slutske, W.S., Martin, N.G. (2014). Personality and gambling involvement: A person-centered approach. Psychology of Addictive Behaviors. 28(4), 1198-1211. PMID: 25134059.

• Savage, J.E. , Mezuk, B. (2014). Psychosocial and contextual determinants of alcohol and drug use disorders in the National Latino and Asian American Study. Drug and Alcohol Dependence, 139, 71-78. PMID: 24742864.