Liza Kok
Contact info
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Address
VU University
De Boelelaan 1085, W&N Bldg, Rm G349
1081 HV Amsterdam
The Netherlands -
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Short CV
| 2020 – | PhD candidate | VU University Amsterdam |
| 2019-2020 | Research Technician | VU University Amsterdam and Amsterdam UMC (location VUmc) |
| 2017-2019 | Master of Science in Neurosciences | VU University Amsterdam |
| 2013‑2017 | Bachelor of Science in Bio-research (Life Sciences & Chemistry) | Hogeschool Inholland Amsterdam |
Research
4H syndrome is are rare genetic disorder which is named after its three characteristic phenotypes: hypomyelination, hypogonadotropic hypogonadism and hypodontia. It is one of the most common hypomyelinating leukodystrophies and currently there are no curative treatments available. The disease is caused by mutations in subunits of RNA polymerase III. Despite the known genetic cause, the understanding of the mechanisms responsible for these three specific phenotypes remains unclear. In my PhD project, we aim to get more insight into the pathomechanisms underlying hypomyelination in 4H syndrome by recapitulating this process in vitro with neurons and oligodendrocytes derived from human induced pluripotent stem cells (hiPSCs).