2009
Bossers, K., Meerhoff, G., Balesar, R., Van Dongen, J., Kruse, C., Swaab, D.F., Verhaagen J. (2009) Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathology 19: 91-107
Blits, B., Verhaagen, J. (2009) Gene therapy for neurological disease. Encyclopedia of Neuroscience (Springer) pp. 1682-1687
Verhaagen, J., Pasterkamp, R.J. (2009) Semaphorins. New Encyclopedia of Neuroscience (Elsevier) pp. 577 – 583.
Hellstrom, M., Ruitenberg, M.J., Pollett, M.A., Ehlert, E.M., Twisk, J., Verhaagen, J., Harvey A.R. (2009). Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection. Gene Therapy 16: 521-532
Vukovic, J., Ruitenberg, M.J., Roet, K., Franssen, E.H.P., Arulpragasam, A., Sasaki, T., Verhaagen, J., Harvey, A.R., Busfield, S.J., Plant, G.W. (2009) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia 56: 1285-1298
Franssen E.H., Roet, K.C., De Bree, F.M., Verhaagen, J. (2009) Olfactory ensheathing glia and Schwann cells exhibit a distinct interaction behaviour with meningeal cells. J. Neurosci. Res. 87: 1556-1564
Tannemaat, M.R., Boer, G.J., Eggers, R., Malessy, M.J., Verhaagen, J. (2009) From microsurgery to nanosurgery: how viral vectors may help to repair the injured peripheral nerve. Prog. Brain Res. 175: 171-186
Harvey, A.R., Ehlert, E.M.E., De Wit, J., Drummond, E., Pollett, M.A., Ruitenberg, M.J., Plant, G.W., Verhaagen, J., Levelt, C.N. (2009) Use of GFP to analyse morphology, connectivity and function of cells in the central nervous system. Methods Mol. Biol. 515: 63-95
MacGillavry, H.D., Stam, F.J., Sassen, M.M., Kegel, L., Hendriks, W.T.J., Verhaagen, J., Smit, A.B., Van Kestern, R.E. (2009) NFIL3 and cAMP Response Element-Binding Protein from a transcriptional feed forward loop that controls neuronal regeneration-associated gene expression. J. Neurosci. 29: 15542-15550
Eggers, R.,Tannemaat, M.R., Ehlert, E.M., Verhaagen, J. (2009) A spatio-temporal analysis of motorneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation. Exp. Neurol., in press
Blits, B., Derks, S., Twisk, J., Ehlert, E.M., Prins, J., Verhaagen, J. (2009) Adeno-associated viral vector (AAV)-mediated gene transfer in the red nucleus of the adult rat brain: comparative analysis of the transduction properties of seven AAV serotypes and lentiviral vectors. J. Neurosci. Meth., in press
2008
Stam, F.J., Mason, M., Smit, A.B., Verhaagen, J. (2008). A meta-analysis of large scale gene expression studies on the injured PNS: towards elucidating the genetic networks underlying successful regeneration. In: Neural regeneration and repair: proteomics and genomics strategies (ed. H.W. Mueller), pp. 35-59
Bossers, K., Meerhoff, G., Balesar, R., Van Dongen, J., Kruse, C., Swaab, D.F., Verhaagen J. (2008) Analysis of gene expression in Parkinson’s disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathology, May 8 Epub.
Franssen, E.H.P., Essing, A., De Bree, F.M., Ramon-Cueto, A., Verhaagen, J. (2008) Comparative gene expression analysis of olfactory ensheathing glia cells and Schwann cells indicated distinct tissue repair characteristics of olfactory ensheathing glia cells. Glia 56: 1285-1298
Eggers R., Hendriks W.T.J., Tannemaat, M., Hoeben, R., Boer, G.J., Carlstedt, T.D., Verhaagen J. (2008) Neuroregenerative effects of the reimplantation of genetically modified spinal roots following avulsion of the spinal motor nerve. Molec. Cell. Neurosci. 39: 105-117
Tannemaat, M.R., Eggers, R., Hendriks, W.T.J., De Ruiter, G.C.W., Van Heerikhuize, J.J., Pool, C.W., Malessy. M.J.A., Boer, G.J., Verhaagen, J. (2008) Differential effects of lentiviral vector-mediated overexpresison of NGF and GDNF on regenerating sensory and motor axons in the transected peripheral nerve. Eur. J. Neurosci., 28(8):1467-79
Tannemaat, M, Verhaagen, J. Malessy, M.J.A. (2008) Gene therapy to treat peripheral nerve injury. Neurological Res., in press
Vukovic, J., Ruitenberg, M.J., Roet, K., Franssen, E.H.P., Arulpragasam, A., Sasaki, T., Verhaagen, J., Harvey, A.R., Busfield, S.J., Plant, G.W. (2008) The glycoprotein fibulin-3 regulates morphology and motility of olfactory ensheathing cells in vitro. Glia, Sep 19 Epub
Verhaagen, J., Pasterkamp, R.J. (2008) Semaphorins. New Encyclopedia of Neuroscience (Elsevier), in press.
Blits, B., Verhaagen, J. (2008) Gene therapy for neurological disease. Encyclopedia of Neuroscience (Springer), in press.
Harvey, A.R., Ehlert, E.M.E., De Wit, J., Drummond, E., Pollett, M.A., Ruitenberg, M.J., Plant, G.W., Verhaagen, J., Levelt, C.N. (2008) Use of GFP to detect and image transduced cells and their connections in the central nervous system. In: GFP in biology (eds. Hicks, B.), in press
2007
Adams, M., Carlstedt, T., Cavanagh, J., Lemon, R.N., McKernan, R., Priestley, J.V., Raisman, G., Verhaagen, J. (2007) International spinal research trust research strategy III: A discussion document. Spinal Cord 45: 2-14
Tannemaat M., Boer G.J., Verhaagen, J., Malessy M. (2007). Genetic modification of human sural nerve segments results in enhanced expression of nerve growth factor. Neurosurgery 61: 1286-1296
De Wit, J., Verhaagen, J. (2007) Proteoglycans and the function of axon guidance molecules. Adv. Exp. Med. Biol. 600: 73-89
Stam, F.J., MacGillavry, H., Amstrong, N., De Gunst, M., Zhang, Y., van Kesteren, R., Smit, A.B., Verhaagen, J. Identification of candidate transcription factors involved in regenerative neurite outgrowth, Eur. J. Neurosci. 25: 3629 – 3637
Hendriks, W.T.J., Eggers, R., Verhaagen, J., Boer, G.J. (2007). Lenti-viral vector- mediated genetic modification of the neural scar: predominat transduction of astrocytes but not meningeal cells, J. Neurosci. Res. 85: 3041-3052
Zhang, Y., Zhang, X., Wu, D., Verhaagen, J., Richardson, P.M., Bo, X. (2007) PSA-NCAM expression in dorsal root entry zone by lentiviral vector mediated expression of polysialotransferease promotes regeneration of sensory axons into the spinal cord, Molecular Therapy 15: 1796-1804
Korecka, J.A., Verhaagen, J., Hol, E.M. (2007) Cellular replacement and gene therapy strategies for Parkinson’s and Alzheimer’s disease. Regenerative Medicine: 2: 425-446
Franssen, E.H.P., De Bree, F.M., Verhaagen, J. (2007) Olfactory ensheathing glia: their contribution to primary olfactory nervous system regeneration and their regenerative potentila following transplantation into the injured spinal cord. Brain Res. Rev.: 56: 236-258
Tannemaat, M.R., Korecka, J., Ehlert, E.M.E., Mason, M.R.J., van Duinen, S.G., Boer, G.J., Malessy, M.J.A., Verhaagen, J. (2007). Human neuroma contains increased levels of semaphorin3A, which surrounds nerve fibers and reduces neurite extension in vitro. J. Neuroscience 27: 14260-14264
2006
Hendriks, W.T.J., Eggers, R., Ruitenberg, M.J., Blits, B., Hamers, F.P.T., Verhaagen, J. and Boer, G.J. (2006) Profound differences in spontaneous long term functional recovery after defined spinal tract lesions in the rat. J.Neurotrauma 23: 18-35.
De Winter, F., Vo, T., Stam, F.J., Wisman L.A.B., Bar, P.R., Niclou, S.P., van Muiswinkel, F.L., Verhaagen, J. (2006) The expression of the chemorepellent semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display a limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Molec. Cell. Neurosci. 32: 102-117
De Wit, J., Eggers, R., Evers, R., Castren, E., Verhaagen, J. (2006) Long-term adeno-associated viral vector-mediated expression of truncated TrkB in adult rat facial nucleus results in motor neuron degeneration. J. Neuroscience 26: 1516-1530
Niclou, S.P., Ehlert, E., Verhaagen, J. (2006) Chemorepulsive guidance molecules in spinal cord injury. J. Neurotrauma 23: 409-421
Pasterkamp, R.J., Verhaagen, J. (2006) Semaphorins and axonal regeneration: developmental guidance cues gone wrong? Phil. Trans. R. Soc. (U.K.) 361: 1499-1511
De Wit, J. Toonen, R., Verhaagen, J., Verhage, M. (2006). Transport of Semaphorin3A is activity-dependent and differs between axons and dendrites. Traffic 7: 1-18
Leaver, S.G., Cui, Q., Plant G.W., Arulpragasam, A., Hisheh, S., Verhaagen, J., Harvey, A.R.(2006) AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Therapy 13: 1328-1341
Harvey, A.R., Hu, Y., Leaver, S.G., Mellough, C.B., Park, K., Verhaagen, J., Plant, G.W., Cui, Q. (2006) Gene therapy and transplantation in CNS repair: the visual system. Prog. Retinal Eye Res. 25: 449-489
Tervonen, T.A., Ajamian, F., De Wit, J., Verhaagen, J., Catsren, E., Castren, M. (2006) Overexpression of truncated TrkB isoform increases the proliferation of neural progenitors. Eur. J. Neurosci. 24: 1277-1285
2005
De Wit, J., De Winter, F., Klooster, J., Verhaagen, J. (2005) Semaphorin3A displays a punctate distribution on the cell surface and interacts with proteoglycans in the extracellular matrix of neuronal cells. Molec. Cell. Neurosci. 29: 40-55
Hu, Y., Leaver, S.G., Plant, G.W., Hendriks, W.T.J., Niclou, S.P., Verhaagen, J., Harvey, A.R., Ciu, Q., (2005) Lentiviral vector-mediated transfer of ciliary neurotrophic factor to Schwann cells within reconstructed peripheral nerve grafts enhances survival and axonal regeneration of adult retinal ganglion cells, Molec. Therapy 11: 906-915
Jimenez, C., Stam, F.J., Wan Li, K, Gouwenbreg, Y., Hornshaw, M.P., De Winter, F., Verhaagen, J., Smit, A.B. (2005) Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Molec. Cell. Proteomics 4: 120-132
Ruitenberg, M.J., Levinson, D.B., Voon Lee, S., Verhaagen, J., Harvey, A.R., Plant, G.W., (2005) NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration. Brain 128: 839-853
Zhang, Y., Bo, X., Schloepfer, R., Holtmaat, A.J.D.G., Verhaagen, J., Emson, P.C., Lieberman, A.R., Anderson, P.N. (2005) Growth-associated protein GAP-43 nad L1 act synergistically to promote rgenerative growth of Purkinje cell axons in vivo. PNAS 102: 14883-14888
2004
Hendriks, W.T.J., Ruitenberg, M.J., Boer, G.J., Verhaagen, J. (2004) Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Progr. Brain Res. 146:451-476.
Dillon, T.E., Saldanha, J., Giger, R., Verhaagen, J., Rochlin, M.W. (2004) Sema3A regulates the timing of target contact by cranial sensory axons. J. Comp. Neurol. 470-13-24.
Ruitenberg, M.J., Blits, B., Dijkhuizen, P.A., te Beek, E.T., Bakker, A., van Heerikhuize, J.J., Pool, C.W., Hermens, W.T.J., Boer, G.J., Verhaagen, J. (2004) Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury. Neurobiol. of Disease, 15: 394-406.
Ahmed, B., Chakravarthy, S., Eggers, R., Hermens, W.T.J.M.C., Zhang, J.Y., Niclou, S.P., Lévelt, C., Sablitzky, F., Anderson, P.N., Lieberman, A.R., Verhaagen, J. (2004) Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors. BMC Neuroscience 5: 4.
Blits,B., Carlstedt,T.P., Ruitenberg,M.J., de Winter,F., Hermens,W.T.J.M.C., Dijkhuizen,P.A., Claasens,J.W.C., Eggers,R., van der Sluis,R., Tenenbaum,L., Boer,G.J., and Verhaagen,J., Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor., Exp. Neurol. 189 (2004) 303-316.
Kas, M.J.H., Tiesjema, B., van Dijk, G., Barner, K.M., Barsh, G.S., Ter Brake, O., Verhaagen, J., Adan, R.A.H. (2004) Induction of brain region specific forms of obesity by Agouti. J.Neurosci. 24: 10176-10181.
De Winter, F., Qui., C., Symons, N., Verhaagen, J., Harvey, A.H. (2004) Expression of Class-3 semaphorins and their receptors in the neonatal and adult rat retina. Investigative Ophthalmology and Visual Science 45: 4554 – 4562.
2003
Blits, B., Oudega, M., Boer, G.J., Bunge, M., Verhaagen, J. (2003) Adeno-associated viral vector-mediated neurotrophin gene transfer improves hindlimb function in the injured adults rat spinal cord. Neuroscience 118: 271-81.
Holtmaat, A.J.G.D., Gorter, J.A., De Wit, J., Tolner E.A., Spijker, S., Giger, R.J., Lopes da Silva, F.H., Verhaagen, J.Exp. Neurol. 182: 142-150. (2003) Transient downregulation of sema3A in a rat model for temporal lobe epilepsy: a novel molecular event potentially contributing to mossy fiber sprouting.
Niclou, S.P., Franssen, E., Ehlert, E.M.E., Taniguchi, M., Verhaagen, J. (2003) Meningeal cell-derived Semaphorin3A inhibits neurite outgrowth. Molec. Cell. Neurosci., 24: 902-912.
Shearer, M.C., Niclou, S.P., Brown, D., Asher, R.A., Holtmaat, A.J.G.D., Levine, J.M., Verhaagen, J., Fawcett, J.W. (2003) The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways. Molec. Cell Neurosci. 24: 913-925.
Ruitenberg, M.J., Plant, G.W., Hamers, F.P.T., Wortel, J., Blits, B., Dijkhuizen, P.A., Gispen, W.H., Boer, G.J., Verhaagen, J. (2003) Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size and functional recovery following implantation in the injured rat spinal cord. J. Neurosci. 23: 7045 – 70 58.
Eisch, A.J., Bolaños, C.A., de Wit, J., Simonak, R.D., Pudiak, C.M., Barrot, M., Verhaagen, J., Nestler, E.J. (2003) BDNF in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol. Psych. 54: 994-1005.
De Wit, J., Verhaagen, J. (2003) Role of semaphorins in the adult nervous system. Prog. Neurobiol. 71: 249-267.