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The axonal cytoskeleton down to the nanoscale

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2024

People

Lara Janssen

PhD student

Lisa Geertjens

Clinician

Daniel Puntman

PhD student

Jovana Kovacevic

PhD student

Hanna Lammertse

PhD student

Annemiek van Berkel

PhD student

Hilgo Bruining

Clinician

Mala Misra

Clinician

Mieke van Haelst

Clinician

Seminars

Education

CNCR Test

PhD candidates Karen Laupman and Nathaniel Bell, with supervisors Associate Professor Vivi Heine and Professor Danielle Posthuma, have been awarded a Proof of Concept (PoC) grant for €55.000 from Amsterdam Neuroscience for their innovative research on repurposing drugs specifically for schizophrenia (SCZ).

Schooling

Teaching

People

Sebastian Quiroz Monnens

PhD student

Janina Kupke

Postdoctoral researcher

Fallon Ratner

University Research Fellow

Lidiia Zhytnik

Postdoctoral researcher

Lotte Smit

Project Manager

Laura Ventura

PhD student

Juliette Chevalier

PhD student

Sophie Lee

PhD student

Pablo de Miguel

PhD student

Lotte Rozemeijer

Technician

Tom Cremer

Postdoctoral researcher

Bastian Meth

PhD student

Zeli Chen

PhD student

Julia Kempff

Technician

Cristina Boers Escuder

PhD student

Thomas Blok

PhD student

Femke Waleboer

PhD student

Jackson Boonstra

Postdoctoral researcher

Natia Shamugia

PhD student

Yves Thönnes

Technician

Tom Coopmans

PhD student

Tongyu Wang

PhD student

Johana Jarkulischova

PhD student

Galia Polak

PhD student

Marcel Oberlaender

Associate Professor

Marianne Kuin

Technician

Kelsey Ax

Management Support

Ana Carreras Mascaro

Postdoctoral researcher

Vivienne Bauer

PhD student

Thijmen Ligthart

PhD student

Romina Ambrosini Defendi

PhD student

Ambika Mahajan

PhD student

Gerda Berkhout

Management Support

Sara Lozano Seoane

Postdoctoral researcher

Hieke van der Veen

University Research Fellow

Kim Verdaasdonk

PhD student

2023

Sandra Parisi

PhD student

Sanne Beerens

Postdoctoral researcher

Iris van den Heuvel

PhD student

2023

2023

2023

Anastasios Mitsigkolas

Technician

Tjerk Swinkels

PhD student

Miranda Moore

PhD student

Contact

People

Kim de Kleijn

Postdoctoral researcher

Neuro-target discovery group

My group uses screening technology to identify novel, targetable disease mechanisms and biomarkers for neurological disorders. We have set-up genome-wide CRISPR-based screening approaches and use these in combination with cellular model systems to: 1) understand the function of unstudied proteins highly abundant in neurodegenerative disorders, 2) uncover novel disease mechanisms, and 3) identify how disease-related processes in brain cells can be reverted.

Ruud Wijdeven

Assistant Professor

Bart Klein

Technician

Projects

2023

Kim Hubregtse

Management Support

Contact

Jobs

Publications

People

Neuronal mRNA trafficking and local translation

Neurons are highly polarized and interactive cells that require precise spatiotemporal regulation of their proteins for proper functioning. To achieve this, neurons have the ability to localize mRNAs and locally synthesize proteins. These processes play key roles in the development, plasticity and maintenance of neurons and dysregulation of these processes are increasingly implicated in neurodegenerative diseases. The main focus of my research group is to understand the molecular mechanisms and functional relevance of mRNA trafficking and local translation in neuronal subcellular compartments in health and disease. In particular, we are interested in the role of the endoplasmic reticulum in regulating mRNA localization and local translation and its role in presynaptic function.

Marina Shiryaeva

PhD student

Max Koppers

Assistant Professor

Laura Guerrero Simón

PhD student

2023

Sascha Koppes

PhD student

Mandy Kater

PhD student

Nicki Covena

PhD student

Lucia Castillo Ransanz

PhD student

Lennert Koomen

Technician

Sylvia Korhorn

Robin Clement

PhD student

Suchita Reddy Enugala

PhD student

Berna Özer

Technician

Adela Vázquez García

Technician

Stan Driessens

PhD student

Walter Pirovano

Project Manager

Jack Smith

PhD student

Tanya Phung

Postdoctoral researcher

Ana Rita Cunha

PhD student

Loek van der Kallen (MCN)

Assistant Professor

News

Research teams

People

Synapse Gene Mapping

Together with the SynGO consortium, we are helping to create an expert-curated knowledge database with information about genes expressed in the synapse, their involvement in biological processes and interaction partners. We aim to add information to the database from our own high-throughput molecular experiments. The low amount of false positives will enable us to perform meaningful and reliable pathway analyses that can aid research into synaptopathies such as autism spectrum disorder and schizophrenia. In addition, my team also focuses on innovative ways to maintain the quality of education with a growing student population.

Loek van der Kallen (FGA)

Assistant Professor

Bernardo de APC Maciel

PhD student

People

Adlin Abramian

PhD student

People

Neurons of human cognition

The main focus of my research is unravelling the cellular basis of human cognition. Traditionally the research on neurobiology of human intelligence focuses on either studying genetic variants associated with intelligence GWAS or imaging of brain areas of intelligence. My ambition is to link these two approaches by studying the function and gene expression in human neurons from neurosurgery in relation to cognition.

Wei Ping Li

PhD student

Marlijn van Baarle

Department Manager

Publications

Robin Clement

PhD student

Panthea Nemat

PhD student

Contact

2022

Jobs

Publications

People

Axon Initial Segment Biology

The axon initial segment is a key compartment in neurons, it is the site of action potential generation. The axon initial segment structure is actively reorganized to accommodate changes in network activity, making this structure an active checkpoint for signal integration. The aim of our research is to unveil the molecular mechanisms controlling axon initial segment plasticity. We want to understand how neurons can adapt to their environment and how this process is altered in neurological disorders.

Amélie Freal

Assistant Professor

2022

Jesica Frik

Postdoctoral researcher

Marjo van der Knaap

Full Professor

2022

2022

2022

2022

People

Kevin Marinus

PhD student

Sylvia Korhorn

PhD student

Additya Sharma

PhD student

Clara Hartmann

PhD student

Matthew Vanheusden

PhD student

Almudena Maroto Juanes

PhD student

Iris Kruijff

PhD student

Aiko Robert

PhD student

Contact

Matthew Vanheusden

Marina Diachenko

Events

2021

Ilan Libedinsky

PhD student

Wouter Peyrot

Postdoctoral researcher

Koen Helwegen

PhD student

Marijn Schipper

PhD student

2021

Amparo Roig Adam

PhD student

Jana Hirzinger

PhD student

Li Qianliang

PhD student

Brendan Lodder

Technician

Gerda Berkhout-ter Huurne

Management Support

Judith Huijgen

Technician

Lauria Claeys

PhD student

News

Neuroticism Summary statistics

Solange Lopes Cardozo

Technician

2021

Lara Janssen

LAVA

LAVA is a tool to conduct genome-wide, local genetic correlation analysis on multiple traits, using GWAS summary statistics as input.

2021

People

Neural circuits of drive

We study how behavioural drives, like feeding, are regulated by hypothalamic and cortical neurons. The lateral hypothalamus is a key controller of feeding and other motivated behaviours. We recently discovered that it does not contain synaptically connected microcircuits, which are ubiquitous in the cortex. On the other hand, key parts of the cortex send input to the lateral hypothalamus. We study these neural pathways with slice electrophysiology and in vivo calcium imaging.

Torben van Voorst

PhD student

Matthieu de Hemptinne

PhD student

Highlights

2021

Vanessa Simões Lourenço

PhD student

Read more about Vanessa Simões Lourenço

Lara Janssen

PhD student

Anna Galakhova

PhD student

Tom Bresser

PhD student

2021

Lisa Geertjens

Rachel Brouwer

Postdoctoral researcher

Pagina niet gevonden

Hilgo Bruining

Zoeken

Dementia Research

Dementia is a major and increasing health problem. Worldwide, 50 million people suffer from dementia and 10 million new cases are diagnosed every year. The most common forms of dementia are Alzheimer’s disease (AD) and frontotemporal dementia (FTD). The progressive cognitive decline associated with AD and FTD presents a huge social and economic burden on our society, and has an immense impact on patients and their families. Dementia is therefore a shared research focus of multiple CNCR teams. Our aim is to identify the pathogenic mechanisms underlying cognitive decline in AD and FTD. We study these mechanisms in models ranging from molecules and cells to animal models and patients. The ultimate goal of our combined research efforts is to contribute to disease modifying therapies and improved early diagnostics for dementia.

People

Dementia Discovery Group

The research in our group focusses on understanding the early cell biological processes that drive Alzheimer’s Disease and other related dementias. We use human stem cell-derived neurons, astrocytes and microglia combined with CRISPR-Cas9 gene-editing to understand how genetic factors drive the earliest stages of disease pathogenesis. We use this knowledge to develop novel drugs for these disorders, with a strong focus on lipid metabolism. - more info coming soon.

Simon Houtman

2018

2019

2020

News

Miriam Öttl

Theresa Priebe

PhD student

Marina Diachenko

PhD student

Mazyar Abdollahi Nejat

PhD student

Biswajit Moharana

PhD student

Current team members

Team members

Internships

Publications

Femke Roig Kuhn

PhD student

Payam Safavi

PhD student

Annetrude de Mooij

Postdoctoral researcher

Alumni

Molecular Engrams

The main goal of my research team is to identify the bio-molecular framework on which aversive associative memories are built and maintained throughout their lifetime.

2020

Debora Pita Illobre

PhD student

Josse Poppinga

PhD student

Chaimaa Bakali

Technician

Mahesh Karnani

Assistant Professor

Karen Laupman

PhD student

Cato Romero

PhD student

Quinty Bisseling

PhD student

Maaike van Boven

PhD student

Fiona Murphy

PhD student

Jasper Smits

PhD student

Patricia Cheruto Kipkemoi

PhD student

2020

Nathaniel Bell

PhD student

Julia van Adrichem

PhD student

Aline Mak

PhD student

State-dependent processing requires critical brain dynamics

Critical brain dynamics is required for state-dependent processing of stimuli Why do we sometimes hear a quiet sound from across the room, but other times we completely miss someone calling our name when they are standing right next to us? Our perception of the world depends not only on the properties of the stimulus, but also on the current functional state of the brain. Empirical evidence indicates that the amplitude and phase of neuronal oscillations reflect fast-changing functional states with the power to determine whether stimuli are consciously perceived or not; however, it was never studied whether these filtering properties depend on additional mechanisms. A new study shedding light on the pre-requisites for state-dependent responses has been published in eLife jointly led by Arthur-Ervin Avramiea and Richard Hardstone from the Neuronal Oscillations and Cognition group of Klaus Linkenkaer-Hansen (PI in the Department of Integrative Neurophysiology). Here, they used a model of neuronal oscillations (CROS) previously developed in the group, which exhibits a phase-transition from weak short-lived oscillations to strong persistent oscillations as the excitation/inhibition ratio is increased. Poised between these regimes is the “critical point” where excitation and inhibition are in balance, and the current activity carries echoes of past activity tens of seconds in the past, whereas away from the critical point, dependence on past activity is quickly lost. In this study, they show that the ability of networks to regulate stimulus response based on pre-stimulus phase or amplitude requires near-critical dynamics, whereas away from the critical state networks show more stereotyped responses. Thus, the brain may bring its dynamics close to the critical state whenever such network versatility is required, or away from the critical state when more reliable responses are required (e.g., when deeply focused). These results could shed light on conflicting results in the literature where phase-dependent responses are only sometimes observed, and potentially explain sensory or attentional deficits through the inability of the network to reach a certain excitation/inhibition state. Linkenkaer-Hansen adds: “I’m particularly excited about this paper because we show how influential theories of the functional significance of neuronal oscillations implicitly depend on critical brain dynamics. This is yet another confirmation of the broad relevance of the criticality framework that we have developed for more than 20 years”. The study was financed by grants from NWO Exact Sciences and NWO Social Sciences, and is published as: Arthur-Ervin Avramiea*, Richard Hardstone*, Jan-Matthis Lueckmann, Jan Bim, Huibert D. Mansvelder, Klaus Linkenkaer-Hansen. Pre-stimulus phase and amplitude regulation of phase-locked responses are maximized in the critical state. (* Joint First Author) eLife 2020;9:e53016.DOI: https://doi.org/10.7554/eLife.53016 Figure: (A) Critical dynamics of neuronal oscillations occur along the excitation-inhibition balanced regime indicated by the black line. Stimulation experiments show that networks show maximum versatility at criticality as indicated by maximum Dynamic Range (B), as well as maximal pre-stimulus Amplitude (C) and Phase (D) regulation of stimulus responses.

Nicole Breeuwsma

Technician

Kevin Batenburg

PhD student

Lauria Claeys

PhD student

Roberto Montoro Ferrer

PhD student

Liza Kok

PhD student

Jorin Heijneman

Technician

Christian Lohmann

Endowed professor

Rik van der Kant

Assistant Professor

2020

2020

2020

2020

Ula Bagińska

PhD student

Miriam Öttl

PhD student

Lotte Razenberg

PhD student

Eline Mertens

PhD student

Jorim Tielbeek

Postdoctoral researcher

Evangelia Thanou

PhD student

Emil Uffelmann

PhD student

2019

2019

2018

2019

2020

2019

JustforFun

2019

Multivariate GWAS

Use the provided simulation script to compare the Type I error rate and power between multiple multivariate genome-wide association tests.

Douglas Wightman

Postdoctoral researcher

Ricarda Weiland

PhD student

Femke Feringa

Postdoctoral researcher

Irune Guerra San Juan

PhD student

Home NL

2019

2019

Marta Jorge Oliva

PhD student

Andrea Romaguera Alvarez

PhD student

Jian Dong

PhD student

Nikki van Bommel

PhD student

Lisa Laan

Technician

Emma Passchier

PhD student

Sven Kerst

PhD student

2019

2018

Suzanne Miedema

PhD student

2018

Mala Misra

Mieke van Haelst

2018

Klaus Linkenkaer-Hansen

Publications

News

People

2018

Connectomics

My research focuses on studying the topological organization of the human brain network, in health and disease. We map and study the human connectome, the ‘road map of the human brain’ and how complex brain function and disfunction may arise from the topological network properties of the human brain network. With my background I bridge psychology, neuroimaging, mathematics, informatics and medicine.

Rory Pijnenburg

PhD student

Siemon de Lange

PhD student

Lianne Scholtens

Postdoctoral researcher

Martijn van den Heuvel

Full Professor

2018

Current internship students

Former internship students

Erika Juárez

PhD student

Marieke Meijer

Daniel Puntman

Niels Cornelisse

2017

Ayoub Khalil

PhD student

.

2018

Eline van Zon

Management Support

test tinca

testt

Lola van Linge

PhD student

Rein Hoogstraaten

PhD student

Ruud Toonen

Jovana Kovacevic

Genetics behind the disease

Research

Clinical information

Matthijs Verhage

Hanna Lammertse

Annemiek van Berkel

Who are we?

2017

Eva van Walree

PhD student

Footer

Contact us

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STXBP1

2017

Test4

Under construction

STXBP1/Munc18-1 disorders

STXBP-Encephalopathy is a severe genetic disease. We, clinical and fundamental researchers at the VU University in Amsterdam, The Netherlands, work together to better understand STXBP1-E. We aim to improve diagnosis and therapeutic interventions, and to provide (animal and cellular) models to study the disease.

Test

Background – STXBP1 disorder

Projects

Jeanne Savage

Postdoctoral researcher

2017

Jean Pie

PhD student

GWAS Summary Statistics

Download summary statistics from GWAS led by our team here

2017

Jobs

Joris Nassal

PhD student

Kim Wolzak

PhD student

Kevin Batenburg

PhD student

FUMA

Use FUMA for post-GWAS functional annotation of genetic variants

Klinische Genetica Balie

KG-balie: multidisciplinair platform tussen kliniek en research.

News

2013 – 2014

2015 – 2016

2017

SPEC 2017

2016

Night at the Museum

Department of Functional Genomics participates in the Museum Night of Amsterdam at NEMO Science Centre

Brain Myths

Myths about the brain are still everywhere in the 21^st century. They can be found in Hollywood movies and self-help books. No matter how popular these ideas about the brain are most of the time they are based on misinterpretations of neuroscientific findings.

Human Brain Project

The HBP aims to put in place a cutting-edge, ICT-based scientific Research Infrastructure for brain research, cognitive neuroscience and brain-inspired computing. The Project promotes collaboration across the globe, and is committed to driving forward European industry.

Research

Internship possibilities

MCN Overview

Overview of MCN research

About us

Students at work: Anouk de Weger (Leiden University) 2015-2016

Students at work: Esther Visser (UvA) 2015

Seminars

Cellomics

In recent years genetics studies have uncovered many genes associated to risk for various brain disorders. This brings the challenge to identify the function of a substantial number of these genes in a neuronal context. In particular, robust standardized screening tools are necessary for cellular gene function analysis.* *
*
High-content screening (HCS), also known as Cellomics, is a microscopy-based method to study gene function or alterations in cellular phenotypes in response to experimental manipulation or treatment. Dedicated HCS instruments, such as the Cellomics ArrayScan VTI and the Opera LX used by us, allow for high-throughput analysis of cells in 96- or 384-well plates and support unbiased and automated image acquisition and analysis. HCS is therefore particularly useful for high-throughput compound and RNAi screens.* *
*
To study neurodevelopmental phenotypes we combine HCS with cultured primary embryonic rodent neurons or iPSC-derived human neurons. We perform both RNAi screens and compound screens and have developed a dedicated image analysis pipeline to extract up to 40 HCS parameters associated with neuronal network development and connectivity.

Learning and Memory

MCN teams aim to understand the process of learning and memory.

Projects

Internships for Bachelor and Master students

2017

Contact

Outreach and Students

The SYNGO Project

The SUN Project

Projects

Contact

Psychiatric disorders

We study depression, anxiety and addiction, as well as schizophrenia, and deficits in attention & inhibitory control

Neurodegenerative disease

We study dementias, such as Alzheimer’s disease and frontal temporal lobe dementia (FTD)

Synapse biology

At the synapse we strive to understand the function of proteins underlying transmission and plasticity

Education

High-content screening

Priyanka Rao-Ruiz

Assistant Professor

2014

2015

MCN lab 2015

2016

MCN lab 2016

Research Overview

Publications MCN

Molecular Mechanisms of Synaptic Plasticity

I aim to mechanistically understand how assemblies of synaptic proteins contribute to synaptic plasticity in health and disease

The Nerve Terminal

Internship projects

Summer School Neurodegeneration

Minor Biomolecular and Neurosciences

Master Neuroscience

Student Internships

Arthur Avramiea

Postdoctoral researcher

Natalia Goriounova

Assistant Professor

Josefin Werme

Postdoctoral researcher

Footer

Teaching

Research

About us

2016-2017

University Research Fellowship

Virtual Brain Experience

A virtual reality experience showing how neurons secrete neuropeptides to influence our development, behavior and emotions

Outreach

Information about valorization

Contact

News

Funding

2016

EM facility contact

Here you find the contact information for transmission electron microscopy (TEM) support.

Jobs

News

Publications

People

People Pages

Research Team Pages

Help

Rogier Min

Assistant Professor

Glial (patho)physiology

We study the interactions between neurons and glial cells, both in the healthy brain and in the context of neurological diseases. In particular we focus on the white matter disease MLC, a disease characterized by dysfunctional astrocyte water and ion homeostasis leading to chronic white matter oedema. Our team is embedded in both the VU University medical center (Department of Childhood Neurology headed by Prof. Marjo van der Knaap) and the CNCR (Department of Integrative Neurophysiology headed by Prof. Huibert Mansvelder).

Vision & Cognition

The Vision and Cognition group is led by Pieter Roelfsema, also director of the Netherlands Institute for Neuroscience. Research of this group is directed at understanding cortical mechanisms of visual perception, memory and plasticity. One of our goals is to create a visual cortical prosthesis to restore vision in blind people.

People Pages

Research Team Pages

Help

People

News

Cortical microcircuits

We want to understand how events at the synaptic and cellular levels are involved in behaviour. To reach this goal, we take a multidisciplinary approach in which we combine electrophysiological recordings and imaging from single neurons and networks of neurons with behaviour. By using molecular interventions, optogenetics and assessing the consequences at different levels of organization, we try to get an understanding of the causal relationships between activity of synapses, neurons, neuronal networks, and cognitive behavior. In collaboration with the Neurosurgery department at the VU medical centre, we study the function of human neuronal circuits to test whether basic principles discovered in rodents hold in human cortical microcircuits.

2016

News

People Pages

Research Team Pages

Help

2016

Research Team Pages

Manage people pages

Help page

Publications

Internship

Christina de Veij Mestdagh

PhD student

People

Psychiatric & Statistical Genomics

Research in this group aims at elucidating underlying biological pathways of brain-related traits and translating these to modifiable targets that can aid in treating brain disorders. We integrate knowledge from different fields, including psychiatry, genetics, neuroscience, machine learning, bioinformatics and mathematics.

2016

Stephanie Dooves

Postdoctoral researcher

2014

2015

Events

People

Genoeconomics

Our group investigates how genes influence economic behavior, and how insights into the genetic architecture of behavioral outcomes can inform social and medical research. We use big data, powerful computers, and advanced quantitative methods for our interdisciplinary work.

2015

News INF

Publications

Footer

Research Teams

Footer

People

People

Footer

Footer

2015

News

People

Research Teams

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CTG

Homepage of Complex Trait Genetics Lab

INF

Research Teams

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FGA

Research Teams

Page not found

MCN

Internship project in bioinformatics

CNCR Seminar Series 2010

CNCR Seminar Series 2016

Teamleader meetings (for teamleaders only)

SPEC 2016

3 PhD-students in cellular neuroscience

SPEC 2015

SPEC 2014

2015

2015

2015

Journal Club

Thursday Presentations

Vivi Heine

Associate Professor

CNCR Seminar Series 2015

Members

Curated geneSets

Expert curated gene-sets that can be used for gene-set analysis.

SPEC 2011

SPEC 2012

SPEC 2013

SPEC 2010

Earlier

Videos

Prob2plinkbig

Use Prob2plinkbig to convert large MACH probability files to PLINK dosage files.

TATES

Use TATES for multivariate GWAS based on P-values from GWAS.

JAMP

Use JAMP for multivariate GWAS analysis, based on raw genotypic data.

iPSc for Complex Traits

CTGlab hosts the VU stem cell lab to generate iPSC derived nerve cells that can be used to study cellular function important for disease.

Filipa Teixeira Borges

PhD student

Mats Nagel

Postdoctoral researcher

2014

Virtual Brain Experience

Philip Jansen

Postdoctoral researcher

MAGMA

MAGMA is a tool for gene analysis and generalized gene-set analysis of GWAS data. It can be used to analyse both raw genotype data as well as summary SNP p-values from a previous GWAS or meta-analysis.

Cesar Vroom

PhD student

News

Christiaan Levelt

Endowed professor

Former lab members

Pizza Meetings

2014

CNCR Seminar Series 2014

2013

Jobs

Jobs

Jobs

Jobs

Jobs

Jobs

Publications

People

Phenotypic modelling in genetics

While twin- and family studies have shown that many traits are considerably heritable, the role of specific genes in heritable traits remains poorly understood and genes that are identified, only explain a small portion of the trait variance. The focus of this group is on modeling complex and dynamic traits in such a way that the probability to uncover the genetic basis is maximized.

Publications

People

Molecular Neurodegeneration

Alzheimer’s disease (AD) is the most common cause of dementia, however, effective treatment or prevention of the disease is not available to date. The aim of our work is to identify early factors that drive the pathogenesis in sporadic AD. We employ different disease models and post-mortem brain material to investigate molecular pathways leading to AD pathology.

Publications

People

Secretory vesicle trafficking and recycling

My research group aims to uncover the molecular mechanisms involved in membrane trafficking and recycling in synapses at nanometer resolution. We study of the transport, docking and fusion of secretory vesicles and the sorting of critical synaptic proteins through endosomes. Endosome recycling is important for the maintenance of basic neurotransmission, but it is also highly dysregulated in neurogenerative diseases such as Alzheimer’s disease. We aim to understand the causal relation between disease progression and the disruption of the endolysosomal pathway.

Wiep Scheper

Associate Professor

Claudia Persoon

Postdoctoral researcher
test

Masters Internship: Information processing in a neuronal network

Klinische Genetica Balie

2013

Marieke Meijer

Postdoctoral researcher

Swati Arora

PhD student

2013

CNCR Seminar Series 2013

2012

News

Jobs

Internship

JAG

Use JAG for gene-set analysis in GWAS datasets.

Jan van Weering

Assistant Professor

2012

Frank Koopmans

Postdoctoral researcher

Jobs

*PhD position in Neuron-Glia interactions in Alzheimer disease* *Project description* We are looking for a candidate for a 4 years PhD project that will be carried out at the CNCR, VU Amsterdam. Recent studies have shown that apart from neurons, glial cells play a major role in synaptic function. As yet, it is unclear to what extent glial cells are also involved in synaptic dysfunction in Alzheimer disease (AD). The overall aim of the project is to obtain insight into the role of glia cells (astrocytes and microglia) in synapse dysfunction at an early stage of AD. The candidate will be involved in the identification of glial factors that are involved in morphological and functional defects of the synapse in AD. The studies will involve analysis of mouse models and human post mortem tissue, using transgenic, proteomic and imaging techniques. We are looking for a candidate with an interest in molecular and cellular neuroscience. Experience with any of the techniques mentioned is an advantage. *Requirements* • MSc degree (or equivalent) in biology or biomedical science; • Research experience in molecular and cellular biology; • Fluent in English (spoken and written). *Further particulars* The initial appointment will be for a period of 1 year. After satisfactory evaluation of the initial appointment, it will be extended for a total duration of 4 years (PhD). You can find information about our excellent fringe benefits of employment at www.workingatvu.nl like: • remuneration of 8,3% end-of-year bonus and 8% holiday allowance; • solid pension scheme (ABP); • a minimum of 29 holidays In case of full-time employment; • a wide range of sports facilities, which staff may use at a modest charge. *Salary* The salary will be in accordance with university regulations for academic personnel, and amounts € 2.222 ,- gross per month in the first year up to € 2.840,- in the fourth year (salary scale 85, PhD) based on a full-time employment. *Information* For additional information please contact: Dr. M. Verheijen Phone number +31 (0)20 59 87120 E-mail: mark.verheijen@vu.nl web: www.cncr.nl *Application* Applicants are requested to write a letter in which they describe their abilities and motivation, accompanied by your curriculum vitae and the names of two scientific referees. Applications should be sent by e-mail before 28 September to: Brigitte Borgman, VU University Amsterdam Faculty of Earth and Life Sciences, CNCR Subject line: Verheijen [vacancy nr, PhD] e-mail: brigitte.borgman@vu.nl

2012

CNCR Seminar Series 2012

2011

2011

News

Memory Circuits

The goal of my team is to gain mechanistic insight into the neural circuitry, cells and molecules that support persistent memories of negative and positive experiences.

Christiaan de Leeuw

Postdoctoral researcher

2011

Software, Resources & GWAS Sumstats

News

News

News

News

News

News

News

News

News

News

News

News

Vacancy for a Master Thesis project

The Neurophysiological Biomarker Toolbox for research on human brain function

2011

Eus van Someren

Endowed professor

Pieter Roelfsema

Endowed professor

Embedding

Word from the director

Tinca Polderman

Assistant Professor

Books

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

Read more about 2010

Sophie van der Sluis

Associate Professor

Data Cohorts & Consortia

CTGlab has initiated data collection of two large scale cohorts: NESCOG and ‘BinnensteBuiten’, and is partner in the ID1000 sample collection of the Spinoza Centre, where it is responsible for genetic analyses.

The Genetic Cluster Computer

CTGlab directs the Dutch Genetic Cluster computer, which provides computing power to hundreds of genetic researchers.

Statistical Genetics

Research projects in CTGlab have a strong focus on developing novel statistical tools to benefit from available genomics datasets and aid in detecting genetic pathways underlying disease.

Psychiatric Genetics

A major theme in our group is to understand underlying causes of psychiatric traits.

Imaging Genetics

CTGlab combines brain imaging and genetics to understand how genetic variation in genes or pathways influences cognitive and psychiatric phenotypes by altering brain structure or function.

Genetic and Biological Pathways

Several research projects at CTGlab focus on optimizing methods to define and model the effects of biological pathways on complex traits.

Danielle Posthuma

Full Professor

Education

Bachelor and Mastercourses in Genetic neuroscience

Jobs

News

News items for Complex Trait Genetics Lab

Publications

People

Research

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2008 – 2009

2005 – 2007

2002 – 2004

CNCR Seminar Series 2011

Publications

Vacancies

Vacancy for PhD position in Glial Regulated Neuronal Plasticity

Yvonne Gouwenberg

Technician

2009

Jaap Timmerman

Technician

Tim Heistek

Technician

2010

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Rolinka van der Loo

Technician

Sabine Spijker

Full Professor

Guus Smit

Full Professor

Brigitte Borgman

Management Support

Student internships

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Braintrain and ONWAR

Our international network

Training Opportunities

A stimulating environment

Joke Wortel

Technician

Ingrid Saarloos

Technician

Robbert Zalm

Technician

Jurjen Broeke

Postdoctoral researcher

Publications

CNCR Seminars

Contact

Joost Verhaagen

Endowed professor

Publications

People

Huib Mansvelder

Full Professor

News

Desiree Schut

Technician

Ruud Toonen

Full Professor

Publications

People

Niels Cornelisse

Assistant Professor

Publications

People

Publications

People

Publications

People

Remco Klaassen

PhD student

Ka Wan Li

Assistant Professor

Publications

People

Klaus Linkenkaer-Hansen

Associate Professor

Publications

People

Rien Dekker

Technician

Publications

Mark Verheijen

Associate Professor

Publications

People

Ronald van Kesteren

Full Professor

Publications

Publications

Publications

Michel van den Oever

Associate Professor

Taco de Vries

Full Professor

People

Publications

Christiaan de Kock

Associate Professor
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People