Highlights 2015-2020

• Hijazi S, Heistek TS, van der Loo R, Mansvelder HD, Smit AB, van Kesteren RE Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta. iScience 2020 Jul 24;23(7):101271. doi: 10.1016/j.isci.2020.101271. Epub 2020 Jun 14.
PMID: 32593000

• Spijker S, Koskinen MK, Riga D Incubation of depression: ECM assembly and parvalbumin interneurons after stress. Neurosci Biobehav Rev. 2020 Jul 17;118:65-79. doi: 10.1016/j.neubiorev.2020.07.015. Online ahead of print.
PMID: 32687884

• Visser E, Matos MR, van der Loo RJ, Marchant NJ, de Vries TJ, Smit AB, van den Oever MC A persistent alcohol cue memory trace drives relapse to alcohol seeking after prolonged abstinence. Sci Adv. 2020 May 6;6(19):eaax7060. doi: 10.1126/sciadv.aax7060. eCollection 2020 May.
PMID: 32494694

• Gonzalez-Lozano MA, Koopmans F, Sullivan PF, Protze J, Krause G, Verhage M, Li KW, Liu F, Smit AB Stitching the synapse: Cross-linking mass spectrometry into resolving synaptic protein interactions. Sci Adv. 2020 Feb 19;6(8):eaax5783. doi: 10.1126/sciadv.aax5783. eCollection 2020 Feb.
PMID: 32128395

• Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla KH, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O’Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron 2019 Jul 17;103(2):217-234.e4. doi: 10.1016/j.neuron.2019.05.002. Epub 2019 Jun 3.
PMID: 31171447

• Hijazi S, Heistek TS, Scheltens P, Neumann U, Shimshek DR, Mansvelder HD, Smit AB, van Kesteren RE Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease. Mol Psychiatry 2019 Aug 20. doi: 10.1038/s41380-019-0483-4. Online ahead of print.
PMID: 31431685

• Rosato M, Stringer S, Gebuis T, Paliukhovich I, Li KW, Posthuma D, Sullivan PF, Smit AB, van Kesteren RE Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes. Mol Psychiatry. 2019 May 29. doi: 10.1038/s41380-019-0436-y.
PMID: 31142819

• Rao-Ruiz P, Couey JJ, Marcelo IM, Bouwkamp CG, Slump DE, Matos MR, van der Loo RJ, Martins GJ, van den Hout M, van IJcken WF, Costa RM, van den Oever MC, Kushner SA Engram-specific transcriptome profiling of contextual memory consolidation. Nat Commun. 2019 May 20;10(1):2232. doi: 10.1038/s41467-019-09960-x.
PMID: 31110186 Free PMC article.

• Matos MR, Visser E, Kramvis I, van der Loo RJ, Gebuis T, Zalm R, Rao-Ruiz P, Mansvelder HD, Smit AB, van den Oever MC Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory. Nat Commun. 2019 May 24;10(1):2315. doi: 10.1038/s41467-019-10266-1.
PMID: 31127098

• Rao-Ruiz P, Yu J, Kushner SA, Josselyn SA Neuronal competition: microcircuit mechanisms define the sparsity of the engram. Curr Opin Neurobiol. 2019 Feb;54:163-170. doi: 10.1016/j.conb.2018.10.013. Epub 2018 Nov 10.
PMID: 30423499

• Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson UH, Li KW, Heine M, Spijker S, Frischknecht R, Smit AB (2018). Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors. Cell Reports, 24(5):1218-1230. doi: 10.1016/j.celrep.2018.06.102
PMID: 30067977

• Riga D, Kramvis I, Koskinen MK, van Bokhoven P, van der Harst JE, Heistek TS, Timmerman AJ, van Nierop P, van der Schors RC, Pieneman AW, de Weger A, van Mourik Y, Schoffelmeer ANM, Mansvelder HD, Meredith RM, Hoogendijk WJG, Smit AB and Spijker S (2017) Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats. Science Translational Medicine 9, DOI: 10.1126/scitranslmed.aai8753
For reprints and full text incl SOM.

• Schmitz LJM, Klaassen RV, Ruiperez-Alonso M, Zamri AE, Stroeder J, Rao-Ruiz P, Lodder JC, van der Loo RJ, Mansvelder HD, Smit AB, Spijker S (2017). The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. eLife, 6, e24192. http://doi.org/10.7554/eLife.24192
PMID: 29199957

• Pandya NJ, Koopmans F, Slotman JA, Paliukhovich I, Houtsmuller AB, Smit AB, Li KW Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution. Sci Rep. 2017;7(1):12107. doi: 10.1038/s41598-017-11690-3.
PMID: 28935861

• van Deijk AF, Camargo N, Timmerman J, Heistek T, Brouwers JF, Mogavero F, Mansvelder HD, Smit AB, Verheijen MH. Astrocyte lipid metabolism is critical for synapse development and function in vivo. Glia 2017 Apr;65(4):670-682. doi: 10.1002/glia.23120. Epub 2017 Feb 7.
PMID: 28168742

• Klaassen RV, Stroeder J, Coussen F, Hafner AS, Petersen JD, Renancio C, Schmitz LJ, Normand E, Lodder JC, Rotaru DC, Rao-Ruiz P, Spijker S, Mansvelder HD, Choquet D, Smit AB. Shisa6 traps AMPA receptors at postsynaptic sites and
prevents their desensitization during synaptic activity. Nat Commun. 2016 Mar 2;7:10682.
PubMed PMID: 26931375

• Hondius DC, van Nierop P, Li KW, Hoozemans JJ, van der Schors RC, van Haastert ES, van der Vies SM, Rozemuller AJ, Smit AB. Profiling the human hippocampal proteome at all pathologic stages of Alzheimer’s disease. Alzheimers Dement. 2016 Jun;12(6):654-68.
PubMed PMID: 26772638.

• Lubbers BR, Matos MR, Horn A, Visser E, Van der Loo RC, Gouwenberg Y, Meerhoff GF, Frischknecht R, Seidenbecher CI, Smit AB, Spijker S, van den Oever MC. The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference. Neuropsychopharmacology 2016 Jun;41(7):1907-16.
PubMed PMID: 26711251

• Schmitz SK, King C, Kortleven C, Huson V, Kroon T, Kevenaar JT, Schut D, Saarloos I, Hoetjes JP, de Wit H, Stiedl O, Spijker S, Li KW, Mansvelder HD, Smit AB, Cornelisse LN, Verhage M, Toonen RF. Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1. EMBO J. 2016 Jun 1;35(11):1236-50.
PubMed PMID: 27056679

• Schreiber J, Végh MJ, Dawitz J, Kroon T, Loos M, Labonté D, Li KW, Van Nierop P, Van Diepen MT, De Zeeuw CI, Kneussel M, Meredith RM, Smit AB, Van Kesteren RE. Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels. J Cell Biol. 2015 Nov 9;211(3):569-86.
PubMed PMID: 26527743

• Fernández E, Li KW, Rajan N, De Rubeis S, Fiers M, Smit AB, Achsel T, Bagni C. FXR2P Exerts a Positive Translational Control and Is Required for the Activity-Dependent Increase of PSD95 Expression. J Neurosci. 2015 Jun 24;35(25):9402-8.
PubMed PMID: 26109663

• Ferreira JS, Schmidt J, Rio P, Águas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL. GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome. J Neurosci. 2015 Jun 3;35(22):8462-79.
PubMed PMID: 26041915

• Wiemhoefer A, Stargardt A, van der Linden WA, Renner MC, van Kesteren RE, Stap J, Raspe MA, Tomkinson B, Kessels HW, Ovaa H, Overkleeft HS, Florea B, Reits EA. Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2. Mol Cell Proteomics 2015 Aug;14(8):2177-93.
PubMed PMID: 26041847

• Chavarria-Siles I, White T, de Leeuw C, Goudriaan A, Lips E, Ehrlich S, Turner JA, Calhoun VD, Gollub RL, Magnotta VA, Ho BC, Smit AB, Verheijen MH, Posthuma D. Myelination-related genes are associated with decreased white matter integrity in schizophrenia. Eur J Hum Genet. 2016 Mar;24(3):381-6. PubMed PMID: 26014434

• Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y. HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Mol Psychiatry 2015 Nov;20(11):1311-21.
PubMed PMID: 25917366

• de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM; Tourette Syndrome Association International Consortium for Genetics., Verheijen MH, Posthuma D. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. Eur J Hum Genet. 2015 Nov;23(11):1519-22.
PubMed PMID: 25735483

• Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM, Whalen MJ, Spijker S, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015 Feb 25;35(8):3397-402.
PubMed PMID: 25716839